|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Although colorectal adenoma recurrence was not significantly influenced by CYP2C9 genotype, carriers of variant UGT1A6 alleles were at significantly reduced risk of colorectal neoplasia recurrence [relative risk (RR), 0.68; 95% confidence interval (95% CI), 0.52-0.89].
|
17085674 |
2006 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Prevalence of predicted intermediate and high activity UGT1A7 and UGT1A6 genotypes was significantly higher in the patients with Warthin's tumors, but not in patients with pleomorphic adenomas, compared with healthy controls.
|
25899702 |
2016 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Polymorphic variation in five UGT and SULT genes - UGT1A1 ((TA)6/(TA)7), UGT2B4 (Asp458Glu), UGT2B7 (His268Tyr), UGT2B15 (Asp85Tyr), and SULT1A1 (Arg213His)--may be associated with circulating sex hormone concentrations, or the risk of an estrogen receptor-negative (ER-) or progesterone receptor-negative (PR-) tumor.
|
15318931 |
2004 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
There were no statistically significant associations between UGT1A1, UGT1A6, or thymidylate synthase genotypes and toxicity or tumor response.
|
15709193 |
2005 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Increased gastrointestinal toxicities were associated with the presence of UGT1A6*2 or UGT1A7*3 and an improved tumour response was noted in those without variant alleles of CYP2A6 or UGT1A1*60.
|
23963147 |
2013 |
|
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Although UGT1A6 genotype was not associated with overall adenoma risk (multivariable odds ratio [OR] = 1.10, 95% confidence interval [CI] = 0.85 to 1.41), functional variant genotypes statistically significantly modified the effect of aspirin on adenoma (P(interaction) = .02).
|
15770010 |
2005 |
|
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk, although further studies will have to be conducted to confirm the association of these variants with colon adenomas.
|
19437564 |
2009 |
|
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
We examined the effect of combining aspirin and celecoxib in relation to UGT1A6 T181A and R184S variants among 1,647 patients in the Adenoma Prevention with Celecoxib (APC) trial who were stratified according to the use of low-dose aspirin after removal of adenomas and randomized to placebo, 200-mg twice daily, or 400-mg twice daily celecoxib for 3 years.
|
22030088 |
2012 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Finally, we also found that the expression of GnT-I was important for cell survival, resistance to cancer drugs, and increased colony formation.
|
30307765 |
2019 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Bilirubin UDP-glucuronosyltransferase 1A1 gene polymorphisms: susceptibility to oxidative damage and cancer?
|
11170257 |
2000 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
UGT1 and UGT2 enzymes have important roles in pharmacology and toxicology including contributing to interindividual differences in drug disposition as well as to cancer risk.
|
30724669 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
UGT1 and UGT2 enzymes have important roles in pharmacology and toxicology including contributing to interindividual differences in drug disposition as well as to cancer risk.
|
30724669 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Finally, we also found that the expression of GnT-I was important for cell survival, resistance to cancer drugs, and increased colony formation.
|
30307765 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Bilirubin UDP-glucuronosyltransferase 1A1 gene polymorphisms: susceptibility to oxidative damage and cancer?
|
11170257 |
2000 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Also, studies have shown that the UGT1 expression is decreased in uroepithelial carcinomas, which may allow for the accumulation of carcinogens in the bladder.
|
27690298 |
2017 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The Implication of the Polymorphisms of COX-1, UGT1A6, and CYP2C9 among Cardiovascular Disease (CVD) Patients Treated with Aspirin.
|
26517138 |
2015 |
|
Colorectal Neoplasms
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk.
|
15319294 |
2004 |
|
Liver diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Among inherited diseases of the liver, Crigler-Najjar type 1 disease (CN-1), which results from complete deficiency in bilirubin UDP-glucuronosyltransferase activity (B-UGT1), is an attractive target for gene therapy studies.
|
17611583 |
2007 |
|
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
UGT1A6, which is expressed abundantly in liver, is not significantly regulated in liver tumors.
|
9230212 |
1997 |
|
Thalassemia
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To test the hypothesis that the variant UDP-glucuronosyltransferase 1A1 (UGT1A1) gene, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and thalassemia influence bilirubin metabolism and play a role in the development of cholelithiasis.
|
16237771 |
2005 |
|
Contact hypersensitivity
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.
|
25724174 |
2015 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
|
28334899 |
2017 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |